Myeloid Cell Leukemia 1

MCL-1 is a member of the apoptosis-regulating BCL-2 family of proteins.1 In normal function, it is essential for early embryonic development and for the survival of multiple cell lineages, including lymphocytes and hematopoietic stem cells.2

A key function of MCL-1 is to inhibit apoptosis

A key function of MCL-1 is to inhibit apoptosis. In tumors, the overexpression of MCL-1 is associated with treatment resistance, relapse, and poor prognosis.3

In addition, independent of its anti-apoptotic activity, MCL-1 has a role in mitochondrial function that may promote cancer cell survival and proliferation. The anti-apoptotic and mitochondrial functions of MCL-1 may synergize to promote tumor progression by inhibiting apoptosis and supporting proliferation.2

References: 1. Thomas D, Powell JA, Vergez F, et al. Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood. 2013;122(5):738-748. 2. Perciavalle RM, Opferman JT. Delving deeper: MCL-1's contributions to normal and cancer biology. Trends Cell Biol. 2013;23(1):22-29. 3. Glaser SP, Lee EF, Trounson E, et al. Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev. 2012;26(2):120-125.